产品详情
产品名称MAP4K3 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用WB IHC
种属反应性Human;Mouse
特异性The antibody detects endogenous levels of total MAP4K3 protein.
免疫原类型Recombinant Protein
免疫原描述Fusion protein corresponding to a region derived from internal residues of human Mitogen-activated protein kinase kinase kinase kinase 3
基因/蛋白名称MAP4K3
标记Unconjugated
别名GLK; MEKKK3; MEKKK 3; MAPKKKK3; RAB8IPL1
数据库入口号Swiss-Prot#: Q8IVH8
NCBI Gene ID: 8491
Gene Accssion: BC071579
Uniprot
Q8IVH8
实际分子量101kd
浓度1.3mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500-1:2000
Immunohistochemistry: 1:25-1:100
Gel: 10%SDS-PAGE
Lysates (from left to right): Mouse heart tissue
Amount of lysate: 50ug per lane
Primary antibody: 1/400 dilution
Secondary antibody dilution: 1/8000
Exposure time: 10 seconds
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using #35951 at dilution 1/30.
This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver.
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et al,Baicalein suppresses growth of non-small cell lung carcinoma by targeting MAP4K3. In Biomed Pharmacother on 2021 Jan by Jian Li, Lijun Yan,et al..PMID:33166766
, (2021),
PMID:
33166766
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