产品详情
产品名称AMIGO2 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用WB IHC
种属反应性Human;Mouse
特异性The antibody detects endogenous levels of total AMIGO2 protein.
免疫原类型Recombinant Protein
免疫原描述Fusion protein corresponding to a region derived from internal residues of human adhesion molecule with Ig-like domain 2
基因/蛋白名称AMIGO2
标记Unconjugated
别名ALI1; DEGA; AMIGO-2
数据库入口号Swiss-Prot#: Q86SJ2
NCBI Gene ID: 347902
Gene Accssion: BC047595
Uniprot
Q86SJ2
实际分子量58kd
浓度2.5mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500-1:2000
Immunohistochemistry: 1:50-1:200
Gel: 6%SDS-PAGE
Lysates (from left to right): SP20 cell and mouse heart tissue
Amount of lysate: 40ug per lane
Primary antibody: 1/615 dilution
Secondary antibody dilution: 1/8000
Exposure time: 2 minutes
Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue using #36094 at dilution 1/50.
The amphoterin-induced gene and ORF (AMIGO) family of proteins consists of AMIGO-1, AMIGO-2 and AMIGO-3. All three members are single pass type I membrane proteins that contain several leucine-rich repeats, one IgG domain, and a transmembrane domain. The AMIGO proteins are specifically expressed on fiber tracts of neuronal tissues and participate in their formation. The AMIGO proteins can form complexes with each other, but can also bind itself. AMIGO-1, also designated Alivin-2, promotes growth and fasciculation of neurites and plays a role in myelination and fasciculation of developing neural axons. In cerebellar neurons, AMIGO-2 (Alivin-1) is crucial for depolarization-dependent survival. Similar to AMIGO-1 and AMIGO-2, AMIGO-3 (Alivin-3) plays a role in homophilic and/or heterophilic cell-cell interaction and signal transduction
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et al,Establishment of an Antibody Specic for AMIGO2 Improves Immunohistochemical Evaluation of Liver Metastases and Clinical Outcomes in Patients with Colorectal Cancer.In
Diagn Pathol on 2022 Jan 30 by Keisuke Goto, Mitsuhiko Osaki,et al..PMID:35094710
, (2021),
PMID:
35094710
et al,Establishment of an antibody specific for AMIGO2 improves immunohistochemical evaluation of liver metastases and clinical outcomes in patients with colorectal cancer. In Diagn Pathol on 2022 Jan 30 by Keisuke Goto, Mitsuhiko Osaki,et al..PMID:35094710
, (2022),
PMID:
35094710
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