产品详情
产品名称USP2 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用IHC
种属反应性Human
特异性The antibody detects endogenous levels of total USP2 protein.
免疫原类型Recombinant Protein
免疫原描述Fusion protein corresponding to residues near the C terminal of human ubiquitin specific peptidase 2
基因/蛋白名称USP2
标记Unconjugated
别名USP9; UBP41
数据库入口号Swiss-Prot#: O75604
NCBI Gene ID: 9099
Gene Accssion: BC002854
Uniprot
O75604
浓度1.7mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Immunohistochemistry: 1:50-1:200
Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue using #36169 at dilution 1/40.
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using #36169 at dilution 1/40.
This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
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et al,Roxadustat ameliorates experimental colitis in mice by regulating macrophage polarization through increasing HIF level. In Biochim Biophys Acta Gen Subj on 2024 Mar by Guiping Kong, Hu Hua,et al..PMID:38158022
, (2024),
PMID:
38158022
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