产品详情
产品名称RICTOR Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用IHC
种属反应性Human
特异性The antibody detects endogenous levels of total RICTOR protein.
免疫原类型Recombinant Protein
免疫原描述Full length fusion protein
基因/蛋白名称RICTOR
标记Unconjugated
别名PIA; AVO3; hAVO3
数据库入口号Swiss-Prot#: Q6R327
NCBI Gene ID: 253260
Gene Accssion: BC029608
Uniprot
Q6R327
浓度2mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Immunohistochemistry: 1:25-1:200
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using #36195 at dilution 1/50.
Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using #36195 at dilution 1/50.
Rapamycin-insensitive companion of mTOR?is a?protein?that in humans is encoded by the?RICTOR?gene. RICTOR and MTOR are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth. Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors.
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et al,MiR-155 enhances phagocytosis of alveolar macrophages through the mTORC2/RhoA pathwayInMedicineOn2023 Sep 1byXinna Yang?1?2,?Xiaoli Zeng et al..PMID: 37657048
, (2023),
PMID:
37657048
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