产品详情
产品名称AIM2 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用IHC
种属反应性Human
特异性The antibody detects endogenous levels of total AIM2 protein.
免疫原类型Recombinant Protein
免疫原描述Fusion protein corresponding to a region derived from internal residues of human absent in melanoma 2
基因/蛋白名称AIM2
标记Unconjugated
别名PYHIN4
数据库入口号Swiss-Prot#: O14862
NCBI Gene ID: 9447
Gene Accssion: BC010940
Uniprot
O14862
浓度3.4mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Immunohistochemistry: 1:50-1:200
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using #36253 at dilution 1/60.
Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using #36253 at dilution 1/60.
Interferon-inducible protein AIM2 (Absent in melanoma 2) is a 343 amino acid protein belonging to the HIN-200 family. Induced by IFN-?, AIM2 is thought to act as a tumor suppressor by repressing NF?B transcriptional activity. Localized to the nucleus, AIM2 contains one DAPIN domain and one HIN-200 domain. The DAPIN domain is composed mostly of ?-helixes and is a protein-protein interaction domain capable of binding other DAPIN domains. The HIN-200 domain has been shown to bind directly to DNA, which, along with the binding of another protein ASC, results in the activation of Caspase-1.?
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et al,Pan-cancer analysis of AIM2 inflammasomes with potential implications for immunotherapy in human cancer: A bulk omics research and single cell sequencing validation.. In Front Immunol on 2022 Sep 29 by Yan Qin, Liuxian Pan,et al..PMID: 36248785
, (2022),
PMID:
36248785
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