产品详情
产品名称INSIG2 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用IHC
种属反应性Human
特异性The antibody detects endogenous levels of total INSIG2 protein.
免疫原类型Recombinant Protein
免疫原描述Fusion protein corresponding to a region derived from internal residues of human insulin induced gene 2
基因/蛋白名称INSIG2
标记Unconjugated
别名INSI2;INSIG2 membrane protein; insulin induced protein 2
数据库入口号Swiss-Prot#: Q9Y5U4
NCBI Gene ID: 51141
Gene Accssion: BC022475
Uniprot
Q9Y5U4
浓度1.4mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Immunohistochemistry: 1:25-1:100
Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue using #36556 at dilution 1/30.
Immunohistochemical analysis of paraffin-embedded Human brain tissue using #36556 at dilution 1/30.
The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi.
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et al,The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis
, (2020),
PMID:
32322062
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