产品详情
产品名称ABI1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用WB IHC
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous levels of total ABI1 protein.
免疫原类型Peptide
免疫原描述Synthetic peptide corresponding to residues near the C terminal of human abl-interactor 1
基因/蛋白名称ABI1
标记Unconjugated
别名E3B1; ABI-1; ABLBP4; NAP1BP; SSH3BP; SSH3BP1
数据库入口号Swiss-Prot#: Q8IZP0
NCBI Gene ID: 10006
Gene Accssion: NP_005461
Uniprot
Q8IZP0
实际分子量55kd
浓度2.3mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500-1:2000
Immunohistochemistry: 1:50-1:200
Gel: 8%SDS-PAGE
Lysates (from left to right): Human fetal brain tissue
Amount of lysate: 40ug per lane
Primary antibody: 1/300 dilution
Secondary antibody dilution: 1/8000
Exposure time: 20 seconds
Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue using #36723 at dilution 1/40.
This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14
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et al,Proteomic characteristics reveal the signatures and the risks of T1 colorectal cancer metastasis to lymph nodes
, (2023),
PMID:
37158593
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