产品详情
产品名称CRH Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用IHC
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous levels of total CRH protein.
免疫原类型Peptide
免疫原描述Synthetic peptide corresponding to residues near the C terminal of human corticotropin releasing hormone
基因/蛋白名称CRH
标记Unconjugated
别名CRF
数据库入口号Swiss-Prot#: P06850
NCBI Gene ID: 1392
Gene Accssion: NP_000747
Uniprot
P06850
实际分子量21kd
浓度1mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:200-1:1000
Immunohistochemistry: 1:25-1:100
Gel: 8%SDS-PAGE
Lysate: 40ug Human placenta tissue
Primary antibody: 1/200 dilution
Secondary antibody dilution: 1/8000
Exposure time: 10 seconds
Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue using #36806 at dilution 1/20.
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using #36806 at dilution 1/20.
Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery.
如果您使用该产品36806发表了文章，请通知我们，让我们可以引用您的文献。
et al,FoxO3a suppresses neuropeptide W expression in neuronal cells and in rat hypothalamus and its implication in hypothalamic-pituitary-adrenal (HPA) axis, In Int J Biol Sci on 2020 Aug 25 by Fengxia Yan, Rikang Wang, et al..PMID: 33061795
, (2020),
PMID:
33061795
et al,Gut microbiota modulates stress-induced hypertension through the HPA axis. In Brain Res Bull on 2020 Sep by Qin Wu, Ziyang Xu, et al..PMID: 32535221
, (2020),
PMID:
32535221
有货
