产品详情
产品名称CTLA4 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用IHC
种属反应性Human;Mouse
特异性The antibody detects endogenous levels of total CTLA4 protein.
免疫原类型Peptide
免疫原描述Synthetic peptide corresponding to residues near the C terminal of human Cytotoxic T-lymphocyte protein 4
基因/蛋白名称CTLA4
标记Unconjugated
别名CD; GSE; GRD4; ICOS; CD152; CTLA-4; IDDM12; CELIAC3
数据库入口号Swiss-Prot#: P16410
NCBI Gene ID: 1493
Gene Accssion: NP_005205
Uniprot
P16410
浓度0.8mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Immunohistochemistry: 1:25-1:100
Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue using #36808 at dilution 1/25.
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
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et al,SLC35A2 expression drives breast cancer progression via ERK pathway activation
, (2023),
PMID:
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