产品详情
产品名称DVL2 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用IHC
种属反应性Human;Mouse
特异性The antibody detects endogenous levels of total DVL2 protein.
免疫原类型Peptide
免疫原描述Synthetic peptide corresponding to a region derived from internal residues of human dishevelled segment polarity protein 2
基因/蛋白名称DVL2
标记Unconjugated
别名Dishevelled-2; DSH homolog 2; DVL2;
数据库入口号Swiss-Prot#: O14641
NCBI Gene ID: 1856
Gene Accssion: NP_004413
Uniprot
O14641
浓度2.1mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Immunohistochemistry: 1:25-1:100
Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using #36830 at dilution 1/20.
Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue using #36830 at dilution 1/20.
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.
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et al,Eurycomalactone switched hepatocellular carcinoma cells into quiescence through 5'tRFAla/DVL/β-catenin pathway inhibition.
, (2025),
PMID:
40128187
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