产品详情
产品名称CBX3 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用WB IHC
种属反应性Human;Mouse
特异性The antibody detects endogenous levels of total CBX3 protein.
免疫原类型Peptide
免疫原描述Synthetic peptide corresponding to residues near the N terminal of human chromobox homolog 3
基因/蛋白名称CBX3
标记Unconjugated
别名HECH; HP1-GAMMA; HP1Hs-gamma
数据库入口号Swiss-Prot#: Q13185
NCBI Gene ID: 11335
Gene Accssion: NP_009207
Uniprot
Q13185
实际分子量21kd
浓度2.4mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500-1:2000
Immunohistochemistry: 1:50-1:200
Gel: 10%SDS-PAGE
Lysates (from left to right): A375 and Raji cell, human fetal brain tissue
Amount of lysate: 40ug per lane
Primary antibody: 1/600 dilution
Secondary antibody dilution: 1/8000
Exposure time: 1 second
Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue using #36926 at dilution 1/40.
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks.?
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et al,E3 ubiquitin ligase Smurf1 promotes cardiomyocyte pyroptosis by mediating ubiquitin-dependent degradation of TRIB2 in a rat model of heart failure
, (2025),
PMID:
39749701
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