产品详情
产品名称API5 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用WB
种属反应性Human
特异性The antibody detects endogenous levels of total API5 protein.
免疫原类型Peptide
免疫原描述Synthetic peptide corresponding to residues near the C terminal of human apoptosis inhibitor 5
基因/蛋白名称API5
标记Unconjugated
别名AAC11; AAC-11
数据库入口号Swiss-Prot#: Q9BZZ5
NCBI Gene ID: 8539
Gene Accssion: NP_006586
Uniprot
Q9BZZ5
实际分子量57kd
浓度2mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500-1:2000
Gel: 10%SDS-PAGE
Lysates (from left to right): 293T and Hela cell
Amount of lysate: 30ug per lane
Primary antibody: 1/250 dilution
Secondary antibody dilution: 1/8000
Exposure time: 2 minutes
This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
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et al,E3 ubiquitin ligase Smurf1 promotes cardiomyocyte pyroptosis by mediating ubiquitin-dependent degradation of TRIB2 in a rat model of heart failure
, (2025),
PMID:
39749701
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