产品详情
产品名称SMAD7 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用WB IHC
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous levels of total SMAD7 protein.
免疫原类型Peptide
免疫原描述Synthetic peptide corresponding to a region derived from internal residues of human SMAD family member 7
基因/蛋白名称SMAD7
标记Unconjugated
别名CRCS3; MADH7; MADH8
数据库入口号Swiss-Prot#: O15105
NCBI Gene ID: 4092
Gene Accssion: NP_005895
Uniprot
O15105
实际分子量46kd
浓度2.1mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500-1:2000
Immunohistochemistry: 1:50-1:200
Gel: 10%SDS-PAGE
Lysates (from left to right): Mouse heart tissue
Amount of lysate: 40ug per lane
Primary antibody: 1/1000 dilution
Secondary antibody dilution: 1/8000
Exposure time: 40 seconds
Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using #37036 at dilution 1/60.
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
如果您使用该产品37036发表了文章，请通知我们，让我们可以引用您的文献。
et al,TGF β1 mediated Smad signaling pathway and EMT in hepatic fibrosis induced by Nano NiO in vivo and in vitro.In Environ Toxicol on 2020 Apr by Zhang Q, Chang X ,et al..PMID: 31737983
, (2020),
PMID:
31737983
et al,ADAMTS13 attenuates renal fibrosis by suppressing thrombospondin 1 mediated TGF-β1/Smad3 activation.
, (2025),
PMID:
39929281
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