产品详情
产品名称SMURF2 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用IHC
种属反应性Human;Mouse
特异性The antibody detects endogenous levels of total SMURF2 protein.
免疫原类型Peptide
免疫原描述Synthetic peptide corresponding to a region derived from internal residues of human SMAD specific E3 ubiquitin protein ligase 2
基因/蛋白名称SMURF2
标记Unconjugated
别名 DKFZp686F0270;SMUF2; SMURF2
数据库入口号Swiss-Prot#: Q9HAU4
NCBI Gene ID: 64750
Gene Accssion: NP_073576
Uniprot
Q9HAU4
浓度1.7mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Immunohistochemistry: 1:25-1:100
Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue using #37124 at dilution 1/15.
Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using #37124 at dilution 1/15.
E3 ubiquitin-protein ligase SMURF2?is an?enzyme?that in humans is encoded by the?SMURF2?gene. E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3.
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et al,Everolimus Alleviates Renal Allograft Interstitial Fibrosis by Inhibiting Epithelial-to-Mesenchymal Transition Not Only via Inducing Autophagy but Also via Stabilizing IκB-α.In Front Immunol. 2022 Jan 24 by Zeping Gui , Chuanjian Suo,et al.PMID: 35140705
, (2022),
PMID:
35140705
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