产品详情
产品名称FZD6 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用IHC
种属反应性Human
特异性The antibody detects endogenous levels of total FZD6 protein.
免疫原类型Peptide
免疫原描述Synthetic peptide corresponding to a region derived from internal residues of human frizzled family receptor 6
基因/蛋白名称FZD6
标记Unconjugated
别名FZ6; FZ-6; HFZ6; NDNC10
数据库入口号Swiss-Prot#: O60353
NCBI Gene ID: 8323
Gene Accssion: NP_001158087
Uniprot
O60353
浓度2.3mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Immunohistochemistry: 1:100-1:300
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using #37296 at dilution 1/60.
Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue using #37296 at dilution 1/60.
This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.
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et al,Integrated analysis of novel macrophage related signature in anaplastic thyroid cancer. In Endocrine on 2022 Dec by Yi Luo, Yi-Chen Yang, et al..PMID:36070052
, (2022),
PMID:
36070052
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