产品详情
产品名称LIN28B Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用WB
种属反应性Human;Mouse
特异性The antibody detects endogenous levels of total LIN28B protein.
免疫原类型Peptide
免疫原描述Synthetic peptide corresponding to residues near the C terminal of human lin-28 homolog B (C. elegans)
基因/蛋白名称LIN28B
标记Unconjugated
别名CSDD2
数据库入口号Swiss-Prot#: Q6ZN17
NCBI Gene ID: 389421
Gene Accssion: NP_001004317
Uniprot
Q6ZN17
实际分子量27kd
浓度1.6mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500-1:2000
Gel: 10%SDS-PAGE
Lysates (from left to right): Mouse liver tissue and k562 cell, hela and 293T cell
Amount of lysate: 40ug per lane
Primary antibody: 1/550 dilution
Secondary antibody dilution: 1/8000
Exposure time: 1 minute
The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012]
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et al,SALL4, a novel marker for human gastric carcinogenesis and metastasis.In Oncogene on 2014 Nov 27 by L Zhang , Z Xu et al..PMID:24276240
, (2014),
PMID:
24276240
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