产品详情
产品名称CAV1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用WB IHC
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous levels of total CAV1 protein.
免疫原类型Peptide
免疫原描述Synthetic peptide corresponding to residues near the N terminal of human caveolin 1, caveolae protein, 22kDa
基因/蛋白名称CAV1
标记Unconjugated
别名CGL3; PPH3; BSCL3; VIP21; MSTP085
数据库入口号Swiss-Prot#: Q03135
NCBI Gene ID: 857
Gene Accssion: NP_001744
Uniprot
Q03135
实际分子量20kd
浓度2.2mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:1000-1:5000
Immunohistochemistry: 1:50-1:200
Gel: 10%SDS-PAGE
Lysates (from left to right): Human fetal muscle and fetal lung tissue, human leiomyosarcoma tissue, mouse lung and heart tissue, NIH/3T3 cell
Amount of lysate: 40ug per lane
Primary antibody: 1/550 dilution
Secondary antibody dilution: 1/8000
Exposure time: 10 seconds
Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue using #37401 at dilution 1/40.
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.
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et al,PTBP3 contributes to the metastasis of gastric cancer by mediating CAV1 alternative splicing.In Cell Death Dis.On 2018 May 1 by PMID: 29752441
, (2018),
PMID:
29752441
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