产品详情
产品名称SH2B2 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用IHC
种属反应性Human
特异性The antibody detects endogenous levels of total SH2B2 protein.
免疫原类型Peptide
免疫原描述Synthetic peptide corresponding to residues near the C terminal of human SH2B adaptor protein 2
基因/蛋白名称SH2B2
标记Unconjugated
别名APS
数据库入口号Swiss-Prot#: O14492
NCBI Gene ID: 10603
Gene Accssion: NP_066189
Uniprot
O14492
浓度4.3mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Immunohistochemistry: 1:25-1:100
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using #37426 at dilution 1/30.
Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue using #37426 at dilution 1/30.
The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway.
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