产品详情
产品名称CD2AP Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用WB IHC
种属反应性Human
特异性The antibody detects endogenous levels of total CD2AP protein.
免疫原类型Peptide
免疫原描述Synthetic peptide corresponding to a region derived from internal residues of human CD2-associated protein
基因/蛋白名称CD2AP
标记Unconjugated
别名CMS
数据库入口号Swiss-Prot#: Q9Y5K6
NCBI Gene ID: 23607
Gene Accssion: NP_036252
Uniprot
Q9Y5K6
实际分子量71kd
浓度3mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:1000-1:5000
Immunohistochemistry: 1:100-1:300
Gel: 6%SDS-PAGE
Lysates (from left to right): A431 and Raji cell
Amount of lysate: 40ug per lane
Primary antibody: 1/1000 dilution
Secondary antibody dilution: 1/8000
Exposure time: 1 second
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using #37468 at dilution 1/70.
This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.
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et al,Tangzhiqing granules alleviate podocyte epithelial-mesenchymal transition in kidney of diabetic rats.In Evid Based Complement Alternat Med on 2017 Jan 10 by Haiyan Xu, Xu Wang,et al..PMID: 28163747
, (2017),
PMID:
28163747
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