产品详情
产品名称EMP2 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用IHC
种属反应性Human
特异性The antibody detects endogenous levels of total EMP2 protein.
免疫原类型Peptide
免疫原描述Synthetic peptide corresponding to a region derived from internal residues of human epithelial membrane protein 2
基因/蛋白名称EMP2
标记Unconjugated
别名XMP
数据库入口号Swiss-Prot#: P54851
NCBI Gene ID: 2013
Gene Accssion: NP_001415
Uniprot
P54851
浓度1.5mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Immunohistochemistry: 1:25-1:100
Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using #37546 at dilution 1/20.
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using #37546 at dilution 1/20.
EMP-2 (epithelial membrane protein 2), also known as XMP, is a 167 amino acid multi-pass membrane protein that contains four-transmembrane domains and belongs to the GAS3/PMP22 (growth arrest-specific-3/peripheral myelin protein-22) family. Localized to lipid raft domains in the plasma membrane, EMP-2 regulates the expression of several target proteins and is necessary for blastocyst implantation in the uterine endometrium. Specifically, EMP-2 mediates blastocyst implantation by controlling the cell membrane expression of MHC and glycosylphosphatidylinositol-anchored proteins, as well as Integrins and caveolin-1. In adult tissues, EMP-2 is expressed in heart, lung, ovary and intestine, while fetal expression is highest in kidney, brain and liver. Overexpression of EMP-2 is associated with endometrial adenocarcinoma, suggesting a possible role for EMP-2 in tumorigenesis.
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et al,Epithelial membrane proteIn 2: a novel biomarker for circulatIng tumor cell recovery In breast cancer. In ClIn Transl Oncol on 2019 Apr by Chen Q, Yao L, et al..PMID:30218306
, (2019),
PMID:
30218306
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