产品详情
产品名称GH1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用WB IHC
种属反应性Human
特异性The antibody detects endogenous levels of total GH1 protein.
免疫原类型Peptide
免疫原描述Synthetic peptide corresponding to a region derived from internal residues of human growth hormone 1
基因/蛋白名称GH1
标记Unconjugated
别名GH; GHN; GH-N; hGH-N; IGHD1B
数据库入口号Swiss-Prot#: P01241
NCBI Gene ID: 2688
Gene Accssion: NP_000506
Uniprot
P01241
实际分子量25kd
浓度2mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:200-1:1000
Immunohistochemistry: 1:50-1:200
Gel: 10%SDS-PAGE
Lysates (from left to right): Human placenta tissue
Amount of lysate: 40ug per lane
Primary antibody: 1/500 dilution
Secondary antibody dilution: 1/8000
Exposure time: 1 second
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using #37591 at dilution 1/40.
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.
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et al,Expression, Purification and Characterization of the Authentic Form of Human Growth Hormone Receptor Antagonist G120R-hGH Obtained in Escherichia Coli Periplasmic Space.In Protein Expr Purif on 2017 Mar by Ana C S C Menezes, Miriam F Suzuki,et al..PMID: 28013084
, (2017),
PMID:
28013084
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