产品详情
产品名称NLRP12 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用IHC
种属反应性Human
特异性The antibody detects endogenous levels of total NLRP12 protein.
免疫原类型Peptide
免疫原描述Synthetic peptide corresponding to a region derived from internal residues of human NLR family, pyrin domain containing 12
基因/蛋白名称NLRP12
标记Unconjugated
别名RNO; PAN6; RNO2; FCAS2; NALP12; PYPAF7; CLR19.3
数据库入口号Swiss-Prot#: P59046
NCBI Gene ID: 91662
Gene Accssion: NP_653288
Uniprot
P59046
浓度1.9mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Immunohistochemistry: 1:25-1:100
Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using #37750 at dilution 1/30.
Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using #37750 at dilution 1/30.
This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants.
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et al,Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its Downstream Interleukin-1β Release Depend on Caspase-4,In Front Microbiol on 2020 Aug 13 by Pei-Hui Ding, Meng-Xin Yang, et al..PMID:32903638
, (2020),
PMID:
32903638
et al,A Novel Role for the Regulatory Nod-Like Receptor NLRP12 in Anti-Dengue Virus Response. In Front Immunol on 2021 Dec 9 by Xingyu Li, Zhuo Dong, et al..PMID:34956178
, (2021),
PMID:
34956178
et al,A Novel Role for the Regulatory Nod-Like Receptor NLRP12 in Anti-Dengue Virus Response. In Front Immunol on 2021 Dec 9 by Xingyu Li, Zhuo Dong,et al..PMID:34956178
, (2022),
PMID:
34956178
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