产品详情
产品名称NLRP6 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用IHC
种属反应性Human
特异性The antibody detects endogenous levels of total NLRP6 protein.
免疫原类型Peptide
免疫原描述Synthetic peptide corresponding to a region derived from internal residues of human NLR family, pyrin domain containing 6
基因/蛋白名称NLRP6
标记Unconjugated
别名AVR; NAVR; PAN3; NALP6; PYPAF5; CLR11.4; NAVR/AVR
数据库入口号Swiss-Prot#: P59044
NCBI Gene ID: 171389
Gene Accssion: NP_612202
Uniprot
P59044
浓度3mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Immunohistochemistry: 1:50-1:200
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using #37752 at dilution 1/50.
Immunohistochemical analysis of paraffin-embedded Human brain tissue using #37752 at dilution 1/50.
The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene.
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et al,Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its Downstream Interleukin-1β Release Depend on Caspase-4,In Front Microbiol on 2020 Aug 13 by Pei-Hui Ding, Meng-Xin Yang, et al..PMID:32903638
, (2020),
PMID:
32903638
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