产品详情
产品名称SIGLEC15 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用IHC
种属反应性Human;Mouse
特异性The antibody detects endogenous levels of total SIGLEC15 protein.
免疫原类型Peptide
免疫原描述Synthetic peptide corresponding to a region derived from internal residues of human sialic acid binding Ig-like lectin 15
基因/蛋白名称SIGLEC15
标记Unconjugated
别名CD33L3; HsT1361; SIGLEC-15
数据库入口号Swiss-Prot#: Q6ZMC9
NCBI Gene ID: 284266
Gene Accssion: NP_998767/Q6ZMC9
Uniprot
Q6ZMC9
浓度2.1mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Immunohistochemistry: 1:25-1:100
Immunohistochemical analysis of paraffin-embedded Human tonsil cancer tissue using #37925 at dilution 1/35.
Immunohistochemical analysis of paraffin-embedded Human prostate cancer tissue using #37925 at dilution 1/35.
Siglec-15 (sialic acid binding Ig-like lectin 15), also known as CD33L3, is a 328 amino acid single-pass type I membrane protein that contains one Ig-like C2-type domain and one Ig-like V-type domain. Expressed in dendritic and macrophage cells, Sinlec-15 interacts with DAP10 and DAP12 and binds to sialylated glycoproteins. The gene encoding Siglec-15 maps to human chromosome 18, which houses over 300 protein-coding genes and contains nearly 76 million bases.
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et al,Metabolic landscape of head and neck squamous cell carcinoma informs a novel kynurenine/Siglec‐15 axis in immune escape. In Cancer Commun (Lond) on 2024 Jun by Xin-Yu Zhang, Jian-Bo Shi,et al..PMID:38734931
, (2024),
PMID:
38734931
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