产品详情
产品名称Insulin Degrading Enzyme Mouse Monoclonal Antibody
来源种属Mouse
克隆性Monoclonal
纯化Affinity purification using immunogen.
应用WB IHC
种属反应性Human
特异性IDE Mouse Monoclonal antibody detects endogenous IDE proteins.
基因/蛋白名称Insulin Degrading Enzyme
标记Unconjugated
Uniprot
P14735
实际分子量118kd
浓度1.0mg/ml
配方Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:1000~1:2000
Western blot analysis of 1) Hela, 2) HepG2, using #38040 diluted at 1:2,000.
Western blot analysis of Hela, HepG2, using #38040 diluted at 1:2,000.
Insulin Degrading Enzyme (IDE) is a large zinc-binding protease of the M16A metalloprotease subfamily known to cleave multiple short polypeptides that vary considerably in sequence. IDE was first identified by its ability to degrade the B chain of the hormone insulin. This activity was observed over fifty years ago, though the enzyme specifically responsible for B chain cleavage was identified more recently.
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et al,FLZ alleviates the memory deficits in transgenic mouse model of Alzheimer's disease via decreasing beta-amyloid production and tau hyperphosphorylation. In PLoS One
on 2013 Nov 4 by Xiu-Qi Bao, Ning Li, et al..PMID: 24223757
, (2013),
PMID:
24223757
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