产品详情
产品名称DCX antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were purified by affinity purification using immunogen.
应用WB,IF
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total DCX protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant protein of human DCX.
基因/蛋白名称DCX
标记Unconjugated
别名DCX;DBCN;DC;LISX;SCLH;XLIS;
数据库入口号Swiss-Prot#: O43602
NCBI Gene ID: 1641
Uniprot
O43602
实际分子量45kd
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
WB 1:500 - 1:2000
IF 1:50 - 1:200
Western blot analysis of extracts of mouse brain, using DCX antibody.
Mutations in Doublecortin cause Lissencephaly (smooth brain), a neuronal migration disorder characterized by epilepsy and mental retardation (1). Doublecortin is a microtubule associated protein that stabilizes and bundles microtubules. A conserved doublecortin domain mediates the interaction with microtubules, and interestingly most missense mutations cluster in this domain (2). Kinases JNK, CDK5 and PKA phosphorylate doublecortin. JNK phosphorylates Thr321, Thr331 and Ser334 while PKA phosphorylates Ser47 and CDK5 phosphorylates Ser297 (3-5). Phosphorylation of Ser297 lowers the affinity of doublecortin to microtubules. Furthermore, mutations of Ser297 result in migration defects (5).
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et al,Naoxinqing tablet protects against cerebral ischemic/reperfusion injury by regulating ampkα/NAMPT/SIRT1/PGC-1α pathwayInJ EthnopharmacolOn2024 Mar 25byXiao Sun?1,?Yunfeng Pan et al..PMID:?38159826
, (2023),
PMID:
38159826
et al,Naoxinqing tablet protects against cerebral ischemic/reperfusion injury by regulating ampkα/NAMPT/SIRT1/PGC-1α pathway. In J Ethnopharmacol on 2024 Mar 25 by Xiao Sun, Yunfeng Pan,et al..PMID:38159826
, (2024),
PMID:
38159826
Yes
