产品详情
产品名称TPH1 antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were purified by affinity purification using immunogen.
应用WB
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total TPH1 protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant protein of human TPH1.
基因/蛋白名称TPH1
标记Unconjugated
别名TPH1;MGC119994;TPRH;TRPH;Tryptophan 5-hydroxylase 1;
数据库入口号Swiss-Prot#: P17752
NCBI Gene ID: 7166
Uniprot
P17752
实际分子量55kd
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500 - 1:2000
Western blot analysis of extracts of THP-1 cell lines, using TPH1 antibody.
Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin (1) by converting tryptophan to 5-hydroxy-L-tryptophan (2). Two isoforms of TPH exist: TPH-1 is mainly expressed in the periphery, whereas the expression of TPH-2 is restricted to neuronal cells and the central nervous system (3). Most of the serotonin found throughout the body is synthesized by TPH-1 in enterochromaffin cells of the gastrointestinal tract. Targeted disruption of the tph1 gene results in low levels of circulating and tissue serotonin (4).
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et al,5-HT2A Receptor and 5-HT Degradation Play a Crucial Role in Atherosclerosis by Modulating Macrophage Foam Cell Formation, Vascular Endothelial Cell Inflammation, and Hepatic Steatosis. In J Atheroscler Thromb on 2021 Feb 2 by Yingying Ma, Xiurui Liang,et al..PMID: 33536397
, (2021),
PMID:
33536397
et al,5-HT2A Receptor and 5-HT Degradation Play a Crucial Role in Atherosclerosis by Modulating Macrophage Foam Cell Formation, Vascular Endothelial Cell Inflammation, and Hepatic Steatosis In J Atheroscler Thromb on 2022 Mar 1 by Yingying Ma, Xiurui Liang,et al..PMID: 33536397
, (2022),
PMID:
33536397
et al,The activation of 5-hydroxytryptamine degradation system in proximal renal tubular epithelial cells induced by renal ischemia-reperfusion injury
, (2021),
PMID:
et al,Nephrotoxicity induced by cisplatin is primarily due to the activation of the 5-hydroxytryptamine degradation system in proximal renal tubules
, (2021),
PMID:
Yes
