产品详情
产品名称HAMP antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were purified by affinity purification using immunogen.
应用WB
种属反应性Human;Mouse
特异性The antibody detects endogenous level of total HAMP protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant protein of human HAMP.
基因/蛋白名称HAMP
标记Unconjugated
别名HEPC; PLTR; HFE2B; LEAP1;
数据库入口号Swiss-Prot#: P81172
NCBI Gene ID: 57817
Uniprot
P81172
实际分子量9kd
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500 - 1:2000
Western blot analysis of extracts of MB435 cell lines, using HAMP antibody.
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Jul 2008]
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PMID:
34311530
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