产品详情
产品名称PTPRA antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were purified by affinity purification using immunogen.
应用WB,IHC
种属反应性Human;Mouse
特异性The antibody detects endogenous level of total PTPRA protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant protein of human PTPRA.
基因/蛋白名称PTPRA
标记Unconjugated
别名LRP; HLPR; PTPA; HEPTP; HPTPA; RPTPA; PTPRL2; HPTPalpha; R-PTP-alpha;
数据库入口号Swiss-Prot#: P18433
NCBI Gene ID: 5786
Uniprot
P18433
实际分子量90kd
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
WB 1:500 - 1:2000
IHC 1:100 - 1:200
Western blot analysis of extracts of various cell lines, using PTPRA antibody at 1:1000 dilution.
Immunohistochemistry of paraffin-embedded human colon using PTPRA antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human kidney using PTPRA antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human stomach using PTPRA antibody at dilution of 1:100 (40x lens).
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported.
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et al,MicroRNA-146a-5p Attenuates Fibrosis-related Molecules In Irradiated and TGF-beta1-Treated Human Hepatic Stellate Cells by RegulatIng PTPRA-SRC SignalIng. In Radiat Res on 2019 Dec by Yuan BY, Chen YH, et al..PMID:31560641
, (2019),
PMID:
31560641
Yes
