产品详情
产品名称GSK3B antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were purified by affinity purification using immunogen.
应用WB,IHC,IF
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total GSK3B protein.
免疫原类型Peptide
免疫原描述A synthetic peptide of human GSK3B.
基因/蛋白名称GSK3B
标记Unconjugated
别名GSK3B; GSK3β;
数据库入口号Swiss-Prot#: P49841
NCBI Gene ID: 2932
Uniprot
P49841
实际分子量48kd
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
IP 1:50 - 1:200
Immunohistochemistry of paraffin-embedded human mammary cancer using GSK3B antibody at dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded human liver cancer using GSK3B antibody at dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded mouse spleen using GSK3B antibody at dilution of 1:200 (40x lens).
Immunofluorescence analysis of C6 cells using GSK3B antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Western blot analysis of extracts of mouse brain, using GSK3B antibody at 1:1000 dilution.
Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin (1). GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β (2,3). GSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development (4). GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization (5).
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et al,Multifunctional Injectable Bioadhesive with Toll-like Receptor 4 and Myeloid Differentiation Factor 2 Antagonistic Anti-inflammatory Potential for Periodontal Regeneration.
, (2025),
PMID:
39951685
Yes
