产品详情
产品名称INS antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were purified by affinity purification using immunogen.
应用WB,IHC,IF
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total INS protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant protein of human INS.
基因/蛋白名称INS
标记Unconjugated
别名ILPR; IRDN; IDDM2; MODY10; Insulin;
数据库入口号Swiss-Prot#: P01308
NCBI Gene ID: 3630
Uniprot
P01308
实际分子量12kd
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Immunofluorescence analysis of rat pancreas using INS antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of mouse pancreas using INS antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded rat pancreatic islet using INS antibody at dilution of 1:50 (40x lens).
Immunohistochemistry of paraffin-embedded mouse pancreatic islet using INS antibody at dilution of 1:50 (40x lens).
Western blot analysis of extracts of mouse pancreas, using INS antibody at 1:1000 dilution.
The maintenance of glucose homeostasis is an essential physiological process that is regulated by hormones. An elevation in blood glucose levels during feeding stimulates insulin release from pancreatic β cells through a glucose sensing pathway (1). Insulin is synthesized as a precursor molecule, proinsulin, which is processed prior to secretion. A- and B-peptides are joined together by a disulfide bond to form insulin, while the central portion of the precursor molecule is cleaved and released as the C-peptide. Insulin stimulates glucose uptake from blood into skeletal muscle and adipose tissue. Insulin deficiency leads to type 1 diabetes mellitus (2).
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et al,Clinical and functional characterization of a novel KCNJ11 (c. 101G> A, p. R34H) mutation associated with maturity-onset diabetes mellitus of the young type 13. In Endocrine on 2024 Nov by Xiaoyu Lv, Jing Gao,et al..PMID:38761346
, (2024),
PMID:
38761346
et al,Clinical and functional characterization of a novel KCNJ11 (c.101G > A, p.R34H) mutation associated with maturity-onset diabetes mellitus of the young type 13
, (2024),
PMID:
Yes
