产品详情
产品名称LCN2 antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were purified by affinity purification using immunogen.
应用WB,IF
种属反应性Human;Mouse
特异性The antibody detects endogenous level of total LCN2 protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant protein of human LCN2.
基因/蛋白名称LCN2
标记Unconjugated
别名LCN2; 24p3; MSFI; NGAL; Lipocalin-2;
数据库入口号Swiss-Prot#: P80188
NCBI Gene ID: 3934
Uniprot
P80188
实际分子量23kd
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
WB 1:500 - 1:2000
IF 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using LCN2 antibody at 1:3000 dilution.
Immunofluorescence analysis of mouse kidney using LCN2 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Lipocalin-2, a member of the lipocalin family of proteins, was originally identified as a gelatinase-associated component of neutrophil secretory granules (1). Lipocalin-2 is involved in innate immunity, iron homeostasis, and apoptosis. Lipocalin-2 limits bacterial growth by binding to bacterial siderophores and sequestering iron (2-4). In mammalian cells, iron-loaded lipocalin-2 binds to its receptor, 24p3R, and is internalized, thereby releasing iron and increasing the intracellular iron concentration (5). Conversely, iron-free lipocalin-2 promotes apoptosis (5). Lipocalin-2 is also expressed in adipose tissue and promotes insulin resistance in cultured mouse adipocytes (6).
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et al,Lipocalin 2 induces visual impairment by promoting ferroptosis in retinal ischemia-reperfusion injury. In Ann Transl Med on 2023 Jan 15 by Tingfang Mei, Jinwen Wu, et al..PMID:36760251
, (2022),
PMID:
36760251
et al,Lipocalin 2 induces visual impairment by promoting ferroptosis in retinal ischemia-reperfusion injuryInAnn Transl MedOn2023 Jan 15byTingfang Mei, Jinwen Wu et al..PMID:36760251
, (2023),
PMID:
36760251
Yes
