产品详情
产品名称CSF1R antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IF
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total CSF1R protein.
免疫原类型Peptide
免疫原描述A synthetic peptide of human CSF1R
基因/蛋白名称CSF1R
标记Unconjugated
别名CSF1R;C-FMS;CD115;CSF-1R;CSFR;FIM2;FMS;HDLS;M-CSF-R;BANDDOS
数据库入口号Uniprot:P07333
GeneID:1436
Uniprot
P07333
Gene ID
1436
实际分子量150-190KDa
浓度1.0mg/ml
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IF 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using CSF1R antibody.
Immunofluorescence analysis of THP-1 cells using CSF1R Rabbit pAb.
Immunofluorescence analysis of mouse bone marrow cells using CSF1R Rabbit pAb.
The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma.
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et al,Stigmasterol alleviates neuropathic pain by reducing Schwann cell‐macrophage cascade in DRG by modulating IL‐34/CSF1R. In CNS Neurosci Ther on 2024 Apr by Waimei Si, Zhenni Chen, et al..PMID:38572785
, (2024),
PMID:
38572785
Yes
