产品详情
产品名称POMC antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were purified by affinity purification using immunogen.
应用WB
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total POMC protein.
免疫原类型Peptide
免疫原描述A synthetic peptide of human POMC.
基因/蛋白名称POMC
标记Unconjugated
别名LPH; MSH; NPP; POC; ACTH; CLIP
数据库入口号Swiss-Prot#: P01189
NCBI Gene ID: 5443
Uniprot
P01189
实际分子量29kd
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500 - 1:2000
Immunohistochemistry: 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using POMC antibody at 1:1000 dilution.
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation.
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et al,Xiaoyaosan decoction regulates food Intake and body weight via the leptIn-leptIn receptor-proopiomelanocortIn pathway In rats with chronic immobilization stress. In J Tradit ChIn Med on 2019 Feb by Wang X, Fang C,et al..PMID:32186021
, (2019),
PMID:
32186021
Yes
