产品详情
产品名称NPHS1 antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IF
种属反应性Mouse;Rat
特异性The antibody detects endogenous level of total NPHS1 protein.
免疫原类型Peptide
免疫原描述A synthetic peptide of human NPHS1
基因/蛋白名称NPHS1
标记Unconjugated
别名NPHS1;CNF;NPHN;nephrin
数据库入口号Uniprot:O60500
GeneID:4868
Uniprot
O60500
Gene ID
4868
实际分子量130kDa
浓度1.0mg/ml
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IF 1:50 - 1:200
Western blot analysis of extracts of mouse kidney, using NPHS1 antibody.
Western blot analysis of extracts of various cell lines, using NPHS1 antibody.
Immunofluorescence analysis of mouse kidney cells using NPHS1 antibody.
This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.
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et al,Chronic high glucose causes podocyte epithelial-mesenchymal transition through lactate-induced histone lactylation
, (2022),
PMID:
et al,Lactate-triggered histone lactylation contributes to podocyte epithelial-mesenchymal transition in diabetic nephropathy in mice.
, (2025),
PMID:
39922521
Yes
