产品详情
产品名称PDK4 antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total PDK4 protein.
免疫原类型Peptide
免疫原描述A synthetic peptide of human PDK4
基因/蛋白名称PDK4
标记Unconjugated
别名PDK4
数据库入口号Uniprot:Q16654
GeneID:5166
Uniprot
Q16654
Gene ID
5166
实际分子量46KDa
浓度1.0mg/ml
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using PDK4 antibody.
Immunohistochemistry of paraffin-embedded rat heart using PDK4 Rabbit pAb.
Immunohistochemistry of paraffin-embedded human placenta using PDK4 Rabbit pAb.
This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin.
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et al,Huzhangoside A Suppresses Tumor Growth through Inhibition of Pyruvate Dehydrogenase KInase Activity. In Cancers (Basel) on 2019 May 23 by Kwak CH, Lee JH, et al..PMID: 31126094
, (2019),
PMID:
31126094
et al,Ilimaquinone Induces the Apoptotic Cell Death of Cancer Cells by Reducing Pyruvate Dehydrogenase Kinase 1 Activity. In Int J Mol Sci on 2020 Aug 21 by Choong-Hwan Kwak, Ling Jin, et al..PMID:32825675
, (2020),
PMID:
32825675
Yes
