产品详情
产品名称APP antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were purified by affinity purification using immunogen.
应用WB;IHC;IF;IP;ELSIA
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total APP protein.
免疫原类型Peptide
免疫原描述A synthetic peptide of human APP.
基因/蛋白名称APP
标记Unconjugated
别名AAA;AD1;PN2;ABPP;APPI;CVAP;ABETA;PN-II;
数据库入口号Swiss-Prot#: P05067
NCBI Gene ID: 351
Uniprot
P05067
计算分子量87kDa
实际分子量100-140kDa
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
WB 1:2000-1:10000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200;
Western blot analysis of extracts from U-87MG and SKOV3 cells using APP antibody.
Immunohistochemistry of paraffin-embedded human stomach using APP antibody.
Immunohistochemistry of paraffin-embedded human esophagus using APP antibody.
Immunohistochemistry of paraffin-embedded Mouse brain using APP antibody.
Immunofluorescence analysis of Hela cell using APP antibody(green) was diluted at 1:200(4° overnight).
Immunofluorescence analysis of D2 cell using APP antibody(green) was diluted at 1:200(4° overnight).
Immunofluorescence analysis of HepG2 cells using APP antibody at dilution of 1:100 (40x lens).
Immunofluorescence analysis of SH-SY5Y cells using APP antibody at dilution of 1:100 (40x lens).
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
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