产品详情
产品名称NPY antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC,IF
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total NPY protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant fusion protein of human NPY (NP_000896.1).
基因/蛋白名称NPY
标记Unconjugated
别名NPY;PYY4
数据库入口号Uniprot:P01303
GeneID:4852
Uniprot
P01303
Gene ID
4852
实际分子量11KDa
浓度1.0mg/ml
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Western blot analysis of extracts of SH-SY5Y cells, using NPY antibody.
Immunohistochemistry of paraffin-embedded mouse spinal cord using NPY Rabbit pAb.
Immunofluorescence analysis of SH-SY5Y cells using NPY Rabbit pAb.
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi.
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et al,Electroacupuncture stimulation induced M1/M2 polarization in white adipose tissues by activating the Y1 receptor in obese mice to reduce chronic inflammation
, (2025),
PMID:
40586350
Yes
