产品详情
产品名称COX4I1 antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IF
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total COX4I1 protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant fusion protein of human COX IV (NP_001852.1).
基因/蛋白名称COX4I1
标记Unconjugated
别名COX4I1;COX IV-1;COX4;COX4-1;COXIV;COXIV-1;COX IV
数据库入口号Uniprot:P13073
GeneID:1327
Uniprot
P13073
Gene ID
1327
实际分子量17kDa
浓度1.0mg/ml
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IF 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using COX IV Antibody.
Immunofluorescence analysis of U2OS cells using COX IV antibody.
Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. Pseudogenes related to this gene are located on chromosomes 13 and 14. Alternative splicing results in multiple transcript variants encoding different isoforms.
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et al,Multifunctional manganese-based nanogels catalyze immune energy metabolism to promote bone repair
, (2025),
PMID:
Yes
