产品详情
产品名称PSMD12 antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total PSMD12 protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant fusion protein of human PSMD12 (NP_002807.1).
基因/蛋白名称PSMD12
标记Unconjugated
别名PSMD12;Rpn5;p55;STISS
数据库入口号Uniprot:O00232
GeneID:5718
Uniprot
O00232
Gene ID
5718
实际分子量53kDa
浓度1.0mg/ml
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
Western blot analysis of extracts of various cell lines, using PSMD12 antibody.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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et al,NSP6 inhibits the production of ACE2-containing exosomes to promote SARS-CoV-2 infectivity. In mBio on 2024 Mar 13 by Xi Lv, Ran Chen,et al..PMID:38303107
, (2024),
PMID:
38303107
Yes
