产品详情
产品名称TXNIP Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用IHC
种属反应性Human
特异性The antibody detects endogenous levels of total TXNIP protein.
免疫原类型Peptide
免疫原描述Synthetic peptide of human thioredoxin interacting protein
基因/蛋白名称TXNIP
标记Unconjugated
别名THIF; VDUP1; HHCPA78; EST01027
数据库入口号Swiss-Prot:Q9H3M7
Gene Accssion:NP_006463
Uniprot
Q9H3M7
浓度3.2mg/ml
配方Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
保存Store at -20˚C
应用详情
Immunohistochemistry:1:30-1:150
Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using #40274 at dilution 1/50.
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
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et al,Fenofibrate suppressed proliferation and migration of human neuroblastoma cells via oxidative stress dependent of TXNIP upregulation.In Biochem Biophys Res Commun
on 2015 May 15 by Cunjin Su, Aiming Shi et al..PMID:25839662
, (2015),
PMID:
25839662
Yes
