产品详情
产品名称PKM Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用IHC
种属反应性Human;Mouse
特异性The antibody detects endogenous levels of total PKM protein.
免疫原类型Peptide
免疫原描述Synthetic peptide of human pyruvate kinase, muscle
基因/蛋白名称PKM
标记Unconjugated
别名PK3; TCB; OIP3; PKM2; CTHBP; THBP1; HEL-S-30
数据库入口号Swiss-Prot:P14618
Gene Accssion:NP_872270
Uniprot
P14618
浓度1.7mg/ml
配方Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
保存Store at -20˚C
应用详情
IHC 1:50-1:200
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using PKM Antibody.
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using PKM Antibody.
This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported.
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et al,Identification of lactate metabolism-related genes for glioma metabolic reprogramming
, (2022),
PMID:
Yes
