产品详情
产品名称PRELP antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification
应用WB, IHC
种属反应性Human;Mouse;Rat
免疫原描述Fusion protein of human PRELP
基因/蛋白名称PRELP
标记Unconjugated
别名MST161; SLRR2A; MSTP161
数据库入口号NCBI Protein#:BC032498
Uniprot
P51888
Gene ID
5549
计算分子量44 kDa
浓度0.9mg/ml
配方pH7.4 PBS, 0.05% NaN3, 40% Glycerol
保存Store at -20˚C/1 year
应用详情
WB dilution:1:500-1:2000
IHC dilution:1:100-1:300
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue lysate, Primary antibody:PRELP Antibody at dilution 1/900, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute
The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using (PRELP Antibody) at dilution 1/120.
The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
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et al,PRELP inhibits colorectal cancer progression by suppressing epithelial-mesenchymal transition and angiogenesis via the inactivation of the FGF1/PI3K/AKT pathway. In Apoptosis on 2024 Sep 6 by Xiaoqing Li, Zhongxiang Jiang,et al..PMID:39242474
, (2024),
PMID:
39242474
Yes
