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SLC7A11 Antibody#43437

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产品详情

产品名称SLC7A11 Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antigen affinity purification.

应用WB IHC

种属反应性Human

特异性The antibody detects endogenous levels of total SLC7A11 protein.

免疫原描述Synthetic peptide of human SLC7A11

基因/蛋白名称SLC7A11

标记Unconjugated

别名xCT; CCBR1

数据库入口号Swiss-Prot#: Q9UPY5
Gene ID: 23657

Uniprot Q9UPY5

计算分子量55kd. 35kd

浓度2.3mg/ml

配方Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

保存Store at -20˚C

应用详情
Western blotting: 1:500-1:2000
Immunohistochemistry: 1:20-1:100
Immunohistochemical analysis of paraffin-embedded Human brain tissue using #43437 at dilution 1/35.
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using #43437 at dilution 1/35.
Western blot analysis of SLC7A11 expression in mouse kidney (A), rat liver (B) whole cell lysates.

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.

如果您使用该产品43437发表了文章，请通知我们，让我们可以引用您的文献。

et al,Pyroptotic macrophages induce disruption of glutamate metabolism in periodontal ligament stem cells contributing to their compromised osteogenic potential. In Cell Prolif on 2024 Oct by Li-Juan Sun, Hong-Lei Qu,et al..PMID:38803043 , (2024),
PMID: 38803043

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注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu人
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk猴
  • Rb兔
  • B牛
  • D狗
  • P猪
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk鸡
;

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400-9961-933
025-58868422

Email Address

info@sabbiotech.com

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