产品详情
产品名称CAMKK2 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用WB
种属反应性Human;Mouse
特异性The antibody detects endogenous levels of total CAMKK2 protein.
免疫原类型peptide
免疫原描述Synthetic peptide of human CAMKK2
基因/蛋白名称CAMKK2
标记Unconjugated
别名CAMKK; CAMKKB
数据库入口号Swiss-Prot#: Q96RR4
Gene ID: 10645
Uniprot
Q96RR4
计算分子量65kd
浓度2.2mg/ml
配方Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:200-1:1000
Gel: 6%SDS-PAGE
Lysate: 40 μg
Lane: Mouse brain tissue
Primary antibody: 1/200 dilution
Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution
Exposure time: 1 minute
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation.
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et al,Artemisinin conferred cytoprotection to human retinal pigment epithelial cells exposed to amiodarone-induced oxidative insult by activating the CaMKK2/AMPK/Nrf2. In J Transl Med on 2024 Sep 16 by Chao Yang, Xia Zhao,et al..PMID:39285426
, (2024),
PMID:
39285426
et al,Artemisinin protected human bronchial epithelial cells from amiodarone-induced oxidative damage via 5'-AMP-activated protein kinase (AMPK) activation.
, (2025),
PMID:
39803706
Yes
