产品详情
产品名称DDC Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification
应用WB
种属反应性Human
特异性The antibody detects endogenous levels of total DDC protein.
免疫原类型peptide
免疫原描述Synthetic peptide of human DDC
基因/蛋白名称DDC
标记Unconjugated
别名AADC
数据库入口号Swiss-Prot#: P20711
NCBI Gene ID: 1644
Uniprot
P20711
计算分子量54kd
浓度0.7mg/ml
配方Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500-2000
Gel: 8%SDS-PAGE
Lysate: 40 μg, Lane 1-2: Human left kidney tissue and Human fetal liver tissue lysates,
Primary antibody:DDC antibody at dilution 1/800,
Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,
Exposure time: 10 seconds
The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
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et al,5-HT2A Receptor and 5-HT Degradation Play a Crucial Role in Atherosclerosis by Modulating Macrophage Foam Cell Formation, Vascular Endothelial Cell Inflammation, and Hepatic Steatosis. In J Atheroscler Thromb on 2021 Feb 2 by Yingying Ma, Xiurui Liang,et al..PMID: 33536397
, (2021),
PMID:
33536397
et al,The activation of 5-hydroxytryptamine degradation system in proximal renal tubular epithelial cells induced by renal ischemia-reperfusion injury
, (2021),
PMID:
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