产品详情
产品名称GANAB Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification
应用IHC
种属反应性Human
特异性The antibody detects endogenous levels of total GANAB protein.
免疫原类型peptide
免疫原描述Synthetic peptide of human GANAB
基因/蛋白名称GANAB
标记Unconjugated
别名APC11; Apc11p; HSPC214
数据库入口号Swiss-Prot#: Q14697
NCBI Gene ID: 23193
Uniprot
Q14697
浓度0.4mg/ml
配方Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
保存Store at -20˚C
应用详情
Immunohistochemistry: 1: 20-100
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using GANAB Antibody at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200)
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using GANAB Antibody at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200)
Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.
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et al,Nephrotoxicity induced by cisplatin is primarily due to the activation of the 5-hydroxytryptamine degradation system in proximal renal tubules
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PMID:
Yes
