产品详情
产品名称CDK14 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification
应用WB
种属反应性Human;Mouse
特异性The antibody detects endogenous levels of total CDK14 protein.
免疫原类型peptide
免疫原描述Synthetic peptide of human CDK14
基因/蛋白名称CDK14
标记Unconjugated
别名PFTK1; PFTAIRE1
数据库入口号Swiss-Prot#: O94921
NCBI Gene ID: 5218
Uniprot
O94921
计算分子量53kd
浓度0.2mg/ml
配方Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:200-1000
Gel: 8%SDS-PAGE
Lysate: 40 μg, Lane: Mouse Pancreas tissue lysate,
Primary antibody:CDK14 antibody at dilution 1/200,
Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,
Exposure time: 10 seconds
Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.
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et al,Upregulated miR-206 Aggravates Deep Vein Thrombosis by Regulating GJA1-Mediated Autophagy of Endothelial Progenitor Cells. In Cardiovasc Ther on 2022 Mar 18 by Yan Li, Jingping Ge, et al..PMID:35360546
, (2022),
PMID:
35360546
Yes
