产品详情
产品名称CACNA2D2 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification
应用IHC
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous levels of total CACNA2D2 protein.
免疫原类型peptide
免疫原描述Synthetic peptide corresponding to internal residues of human CACNA2D2
基因/蛋白名称CACNA2D2
标记Unconjugated
别名CACNA2D
数据库入口号Swiss-Prot:Q9NY47
NCBI Gene ID:9254
NCBI Protein:NP_001167522
Uniprot
Q9NY47
浓度1.1mg/ml
配方Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
保存Store at -20˚C
应用详情
Immunohistochemistry: 1: 30-150
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using 46384(CACNA2D2 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: x200)
Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.?
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et al,Exploring diverse programmed cell-death patterns to develop a novel gene signature for predicting the prognosis of lung adenocarcinoma patients
, (2024),
PMID:
Yes
