产品详情
产品名称CASR Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification
应用WB IHC
种属反应性Human
特异性The antibody detects endogenous levels of total CASR protein.
免疫原类型peptide
免疫原描述Synthetic protein corresponding to residues near the C terminal of human CASR
基因/蛋白名称CASR
标记Unconjugated
别名CAR; FHH; FIH; HHC; EIG8; HHC1; NSHPT; PCAR1; GPRC2A; HYPOC1
数据库入口号Swiss-Prot:P41180
NCBI Gene ID:846
NCBI Protein:BC112236
Uniprot
P41180
计算分子量121 kDa
浓度0.7mg/ml
配方Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:200-1:1000
Immunohistochemistry: 1: 50-300
Gel: 6%SDS-PAGE
lysate: 40 ¦Ìg, Lane: Hela cell lysate,
Primary antibody: 46408£¨CASR Antibody) at dilution 1/450
Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,
Exposure time: 2 minutes
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using 46408(CASR Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200)
The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.
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et al,Acetylcholine protects mesenteric arteries against hypoxia/reoxygenation injury via inhibiting calcium-sensing receptor.In J Pharmacol Sci on 2015 Apr by Ming Zhao , Xi He et al..PMID:25922231
, (2015),
PMID:
25922231
Yes
